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헤파라나제 활성 측정용 이온 복합체 나노 입자 및 그 제조 방법
| 대표분류 | 의약,의료,화장품 | 구분 | 소액무상특허 |
|---|---|---|---|
| 기술테마 | 의약,의료,화장품 | ||
| 연구기관 | 한국과학기술연구원 | 연구자 | 김광명 |
| 기술내용 | 이전대상 특허번호: 8323622(미국) 이전유형: 양도 이전비용 : 1천만원 비고: 부가세별도 Disclosed are Ionic complex nanoparticles for detecting heparanase activities and a method for preparing the same. More specifically, disclosed are Ionic complex nanoparticles for detecting heparanase activities, wherein negative-ion substrate polymers specifically degraded by heparanase and positive-ion biocompatible polymers ionically bind to each other, and fluorophores or quenchers bind to each of the polymers. The ionic complex nanoparticles for detecting heparanase activities may be applied to a method for screening novel drugs such as inhibitors that prevent over-expression of heparanase. Various cells and tissues where over-expression of heparanase occurs may be non-invasively imaged in cancer cells, cancer tissues, and tissues of various inflammatory diseases. Accordingly, the ionic complex nanoparticles for detecting heparanase activities may be effectively used to early diagnose various diseases and incurable diseases including autoimmune diseases such as cancers, osteoarthritis, rheumatoid arthritis, and dementia. |
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